Kara Crisp, 23, is charged in Benton Circuit Court with operating a vehicle with a controlled substance causing death, a Class B felony; operating a vehicle with a blood-alcohol content of 0.08 percent or more causing death, a Class C felony; and reckless homicide, a Class C felony.
The charges were filed in November after a grand jury indictment.
Benton County prosecutor Bill Weist said Crisp's trial, which is scheduled to begin Wednesday, could last up to three days.
Crisp is accused of driving a 1999 Jeep Grand Cherokee on Indiana 352 near Boswell the morning of May 26, 2007, that rolled several times and came to a rest on its side in a cornfield.
Crisp and her two passengers, Jeremy A. Bell, 22, of Fowler and Ismael Carabello III, 22, of Boswell, were thrown from the Jeep.
No one was wearing a seat belt.
Bell died at the scene. Crisp and Carabello both suffered internal injuries and were treated at Methodist Hospital in Indianapolis.
Crisp is suspected of having marijuana metabolites and alcohol in her system at the time of the crash. Indiana law requires only that narcotic metabolites be present to establish impaired driving.